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Radiation treatment plus platinum-based chemotherapy may extend survival times in advanced lung cancer.

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PFS was defined as the interval from the date of randomization to the date of objective disease progression (as per RECIST) or the date of death (from any cause) in the absence of objective disease progression.

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Conversely, mucinous BAC, always negative for EGFR mutations, were frequently affected by codon 12 mutations of the K-ras gene.

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Stage IV NSCLC: Maximum 4 cycles if disease not responding to treatment; maximum 6 cycles of chemotherapy if disease responds to treatment.

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Afatinib plus cetuximab (Erbitux) may be considered in patients who progress on EGFR tyrosine kinase inhibitor treatment, particularly in T790M-negative patients.

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First-SIGNAL: first-line single-agent iressa versus gemcitabine and cisplatin trial in never-smokers with adenocarcinoma of the lung.

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And if your mother did have the EGFR mutation, she could perhaps go on one of the clinical trials Janine linked to, where she would get Tarceva (similar to Iressa) for free.

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The mature results of two studies that investigated osimertinib at the recommended 80-mg dose in EGFR-mutated and T790M-positive NSCLC patients who had disease progression on previous EGFR tyrosine kinase inhibitor therapy found that response rates were 71% in the phase I dose-expansion cohort of 63 patients and 66% in pooled results from two phase II studies of 411 patients.

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In theory, all of these drugs should work better, because they block the communication pathways hijacked by the genetic mutations that become cancer.

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The second ALK-rearranged NSCLC patient was a 30-year-old male never-smoker enrolled into the trial at Beth Israel Deaconess Medical Center, Boston, MA on June 5, 2008, onto the 200 mg orally twice a day cohort and achieved stable disease for several months.

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Iressa "survivor population" is only about 15% of those who were put on it.

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IgG1 insulin-like growth factor (IGF) monoclonal antibody targeting the IGF ligands 1 (IGF-1) and 2 (IGF-2), with potential antineoplastic activity.

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However, those who do it say that, with hindsight, they wish they had got involved much earlier.

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ZD1839 (IRESSA), an EGFR-selective tyrosine kinase inhibitor, enhances taxane activity in bcl-2 overexpressing, multidrug-resistant MCF-7 ADR human breast cancer cells.

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We previously reported that topoisomerase I up-regulation by counter-part drugs was a possible mechanism for the synergy in an CPT-11 containing regimen.

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These patients are much more likely to have classical EGFR mutations in the small cell component of their tumors as well, and their tumors seem to be more likely to respond to treatment with EGFR-TKI's.

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In contrast, non-small cell lung carcinomas (NSCLC's) are more likely to remain localized to the during development, and are thus more amenable to cure using radical surgical resection.

The therascreen EGFR RGQ PCR Kit is a real-time PCR test for the qualitative detection of exon 19 deletions and exon 21 (L858R) substitution mutations of the epidermal growth factor receptor (EGFR) gene in DNA derived from formalin-fixed paraffin-embedded (FFPE) non-small cell lung cancer (NSCLC) tumor tissue.

This is generally not recommended outside of a clinical trial, however.

The researchers then watched to see what happened to the participants.

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Erythropoietin is available as epoetin alfa (Epogen, Procrit) and darbepoetin alfa (Aranesp), which requires fewer injections.

By the time the tarceva trial came out and it was approved by the FDA, gefitinib was relegated to a secondary role in the US, but it has always fared better in Asia, where it continues to be widely used.

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These studies get much attention in the media, but it is often much ado about nothing.

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After Iressa becomes ineffective, what do we do next?

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The subset population consisted of 186 patients with metastatic NSCLC whose tumors have EGFR 19 deletions or exon 21 (L858R) substitution mutations as determined by the same assay used in IPASS as well as radiographic scans available for retrospective analysis by BICR.

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