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In addition, one trial compared allopurinol 300 mg daily versus allopurinol 100 mg three times daily (), and one trial compared continuous versus two months per year of allopurinol ().

Also note that interaction between two medications does not always mean that you must stop taking one of them.

Dosierungen über 300 mg sollten in zwei oder mehr kleinere Dosen aufgeteilt werden.

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None of the trials reported on other outcomes of interest including function, health-related quality of life or participant global assessment of treatment success, where further research would be useful for clinical practice.

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There are few reports describing the use of allopurinol during pregnancy; no adverse fetal outcomes attributable to allopurinol have been reported in humans; use only if potential benefit outweighs the potential risk to the fetus.

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Duration of treatment was at least one year and 55 participants received treatment for two years.

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The explanation for this decrease has not been determined, but it may be due to following recommended usage (see ADVERSE REACTIONS introduction, INDICATIONS AND USAGE, PRECAUTIONS, and DOSAGE AND ADMINISTRATION).

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The clinical basis of this drug interaction has not been established but should be noted when Allopurinol is given to patients already on dicumarol therapy.

Use of azathioprine or 6-mercaptopurine on the background of allopurinol permits a 4-fold reduction in their doses.

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Allopurinol cannot be used in patients with hypersensitivity to the medication, in individuals with a hepatic or renal disorders, primary hemochromatosis, asymptomatic hyperuricemia, acute gout, pregnancy, lactation.

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After 10 days, participants in the placebo arm were also started on allopurinol 300 mg daily.

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You may experience acute attacks of gout more often at the beginning of treatment with Allopurinol even after normal uric acid levels are reached.

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Pharmacokinetic and pharmacodynamic interaction between allopurinol and probenecid in patients with gout.

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Instead of asking whether you had an attack of gout during the study period, it should have been "HOW MANY attacks did you have over the study period?

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Allopurinol 300 mg daily probably does not reduce the incidence of acute gout attacks when compared with placebo over 30 days, and allopurinol 100 to 600 mg daily may not reduce acute gout attacks compared with benzbromarone 100 to 200 mg daily or febuxostat 80 mg daily over 16 to 24 weeks.

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Safety, as assessed by the number of study participant withdrawals due to AEs and SAEs, were not reported in this trial.

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However, we found no between-group differences between allopurinol up to 300 mg daily and febuxostat 80 mg daily with respect to acute gout attacks and no between-group differences between allopurinol 200 or 300 mg daily and febuxostat 40 mg daily with respect to serum urate normalisation.

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Effects of febuxostat versus allopurinol and placebo in reducing serum urate in subjects with hyperuricemia and gout: a 28-week, phase III, randomized, double-blind, parallel-group trial.

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Among 55 patients with gout treated with Allopurinol for 3 to 34 months (average greater than 1 year) and followed prospectively, Rundles observed that 3% of patients developed a type of drug reaction which was predominantly a pruritic maculopapular skin eruption, sometimes scaly or exfoliative.

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One additional person treated with benzbromarone was temporarily taken off of treatment when he developed diarrhoea and was not included in this analysis as benzbromarone was successfully re-started and the AE was determined to be a result of colchicine ().

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Our review did not identify any RCTs or CCTs that used allopurinol in doses as high as 800 mg daily, although one trial titrated the dose to 600 mg daily, which enabled achievement of the target serum urate target level ().

Two trials used a computer-generated central randomisation schedule with block sizes of three to six to randomise participants (; ); one trial used an interactive voice response system to initiate double-blind randomisation (), and one trial used a random number generator ().

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The dosage of Allopurinol to accomplish full control of gout and to lower serum uric acid to normal or near-normal levels varies with the severity of the disease.

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