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Impact of urinary incontinence after stroke: results from a prospective population-based stroke register.

Efficacy and tolerability of darifenacin, a muscarinic M3 selective receptor antagonist (M3 SRA), compared with oxybutynin in the treatment of patients with overactive bladder.

Preserving cognitive function for patients with overactive bladder: evidence for a differential effect with darifenacin.

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Methods: A Pubmed search was carried out differentiating randomised, clinical trials; longitudinal, retrospective studies; and metanalysis on the use of tolterodine for overactive bladder treatment.

The decision algorithm for the initiation of treatment for biochemical failure is controversial.

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Abnormal findings might be present in patients with cystitis, constipation, neurogenic bladder, urethral obstruction, ectopic ureter, or obstructive sleep apnea (OSA).

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Second, the reaction of compound 8 to give compound 9 requires a large amount of Na.

Prompt adequate treatment of UTI can prevent the spread of infection and renal scarring.

Mirabegron had an advantage with regard to side effects: Dry mouth was less common in comparison with tolterodine.

I-A) To decrease side effects, switching to a lower dose or using an extended release formulation or a transdermal delivery mechanism should be considered.

High-resolution genomic profiling of male breast cancer reveals differences hidden behind the similarities with female breast cancer.

While many have been associated with in young animals, animal experiments have found that topiramate is the only anticonvulsant that does not induce apoptosis in young animals at doses needed to produce an anticonvulsant effect.

When parkinsonism occurs early in the coarse of the disease, as happens in patients with PNFA, a trial of dopamine agonist therapy should be considered.

One of the main limitations of anti-muscarinic therapy is that the majority of patients discontinue after a few weeks or months.

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Despite highly controlled conditions to minimize adverse effects, 22% of subjects (8 of 36) had notable experiences of fear or paranoia.

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Efficacy of simplified bladder training in patients with overactive bladder receiving a solifenacin flexible-dose regimen: results from a randomized study.

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Although a few patients in both treatment groups (8% in placebo and 4% in tolterodine ER) reported UUI episodes at study end, considering the limitations of this study, it cannot be determined if these patients developed UUI during the 12-week treatment period or if their sporadic UUI episodes at baseline were not captured in a 7-day diary.

Treat UTIs with four to seven day courses of oral or parenteral therapy.

Although nocturnal polyuria is presumed to be the cause of the bedwetting, a disorder of arousal is also likely to be present because most school-aged patients develop nocturia but maintain a dry bed.

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Each micturition was categorized by urgency rating: total (urgency rating 1-5), non-OAB (1-2), OAB (3-5), and severe OAB (4-5).

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These interventions still show no benefit in terms of pain or function but also have not been shown to cause adverse shoulder contracture according to a recent literature review.

Recommendation: As prazosin and the nonselective alpha-blocker phenoxybenzamine were not reviewed in the course of this Guideline revision, the 2003 Guideline statement indicating that the data were insufficient to support a recommendation for the use of these two agents as treatment alternatives for LUTS secondary to BPH has been maintained.

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Sieber PR, Rommel FM, Huffnagle HW et al: The treatment of gross hematuria secondary to prostatic bleeding with finasteride.

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The age at which surgical intervention for an undescended testis happens seems to be an important predictive factor for fertility later in life.

Safety information from a study of a total of 710 pediatric patients (486 on DETROL LA, 224 on placebo) is available.

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Specific dysfunction in the external urethral sphincter can develop after pelvic extirpative surgery, radiation therapy for pelvic malignancy, pelvic fracture, or incontinence surgery.

In Phase 1, multiple-dose studies in which tolterodine immediate release 4 mg (2 mg bid) was administered, serum concentrations of tolterodine and of the 5-hydroxymethyl metabolite were similar in healthy elderly volunteers (aged 64 through 80 years) and healthy young volunteers (aged less than 40 years).

Amico et al reported higher overall survival with the combination of radiation therapy and 6 months of ADT in men with intermediate-risk prostate cancer.

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Excretion: Following administration of a 5 mg oral dose of 14C-tolterodine solution to healthy volunteers, 77% of radioactivity was recovered in urine and 17% was recovered in feces in 7 days.

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AUC) determined after dosage of tolterodine immediate-release are dose-proportional over the range of 1 mg to 4 mg.

The original manufacturer uses a brand name whereas a generic drug is usually called by the name of the active ingredient.

Click on citations within drug and disease topics in our clinical reference to review the clinical evidence on MEDLINE.

Jamil (2001) stated that the Finetech-Brindley stimulator can be recommended to female patients after 3 months and to male patients after 9 months of complete supra-sacral SCI.

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Moreover, these older agents do not appear to increase the risk of the intraoperative floppy iris syndrome (IFIS), and doxazosin has demonstrated efficacy relative to placebo over four years of follow-up.

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Central diabetes insipidus may result from an intracranial tumor, head trauma, encephalitis, or meningitis; nephrogenic diabetes insipidus may result from any cause of renal failure, diffuse renal cortical or medullary damage, hypokalemia, hypercalcemia, or nephrotoxic drugs.

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The formation of N-dealkylated tolterodine was detected in microsomes overexpressing not only CYP3A4 but also CYP2C9 and -2C19.

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Overdosage with tolterodine tartrate tablets can potentially result in severe central anticholinergic effects and should be treated accordingly.

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The transdermal patch of oxybutynin is no more effective than the short- or long-acting oral form.

Improvement in walking speed in poststroke spastic hemiplegia after intrathecal baclofen therapy: a preliminary study.

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OAB medication studies generally are not conducted in the frail elderly, resulting in a lack of data in this group.

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Notably, the average change in these variables was more marked for those patients on active treatment who reported an improvement.

Special Considerations: Drugs Affecting the Central Nervous System Psychoactive drugs have an effect on the brain and are among the most frequent medications given to the elderly.

The sessions were scheduled by the patients when they felt they needed a treatment.

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Monitoring during implantation and 6-monthly follow-ups were performed; 6 of the implanted 8 patients completed the study (1 was lost to follow-up; 1 died from pneumonia).

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The 12-year symptomatic outcome of transurethral resection of the prostate for patients with lower urinary tract symptoms suggestive of benign prostatic obstruction compared to the urodynamic findings before surgery.

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CONCLUSION: Tolterodine (taken for 4 weeks) is safe and shows efficacy, particularly at a dosage of 2 mg bid, in the treatment of older patients with urinary symptoms attributable to overactive bladder.

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Yazdany (2011) also reported on testing phase success in a group of patients with severe incontinence (mean 10.

All residents, regardless of the use of an indwelling catheter, receive the appropriate care and services to prevent urinary tract infections.

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Patient groups reported similar global improvement rates (81% of onabotulinumtoxinA group; 90% of abobotulinumtoxinA group).

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Wilt T, Ishani A, Rutks I et al: Phytotherapy for benign prostatic hyperplasia.

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Aetna considers electrical stimulation of the sacral anterior roots (by means of an implanted stimulator, the Vocare Bladder System) in conjunction with a posterior rhizotomy medically necessary for members who have clinically complete spinal cord lesions (American Spinal Injury Association Classification) with intact parasympathetic innervation of the bladder and who are skeletally mature and neurologically stable, to provide urination on demand and to reduce post-void residual volumes of urine.

Some affected individuals develop abnormalities of the eyes including nystagmus during childhood and macular degeneration, pigmented retinal degeneration and decreased clarity of vision (visual acuity) during adulthood.

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However, its drug form, physostigmine salicylate, has poor bioavailability.

Potent CYP3A4 inhibitors: The effect of a 200 mg daily dose of ketoconazole on the pharmacokinetics of tolterodine immediate release was studied in 8 healthy volunteers, all of whom were CYP2D6 poor metabolizers.

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Oerlemans DJAJ, Van Voskuilen AC, Marcelissen T et al: Is on-demand sacral neuromodulation in patients with OAB syndrome a feasible therapy regime?

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Success rates (defined as PPBC score improvement of two or more points) were statistically similar at 56% for DM patients and 61% for non-DM patients and remained at 6 months.

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