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What is a depressant drug? A depressant, or central depressant, is a drug that lowers neurotransmission levels, which is to depress or reduce arousal or stimulation, in various areas of the brain. Depressants are also occasionally referred to as "downers" as they lower the level of arousal when taken.
What is the best antidepressant for weight loss? Antidepressants that are less likely to cause weight gain escitalopram (Lexapro, Cipralex), an SSRI. duloxetine (Cymbalta), a serotonin-norepinephrine reuptake inhibitor (SNRI), may cause modest weight gain with long-term use. bupropion (Wellbutrin, Forfivo, and Aplenzin), an atypical antidepressant.


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