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Does it matter what time of day you take antidepressants? 'Ideally take them at around the same time each day. That way the medication can build up in a steady way to have the best effect. 'If you develop a routine, then it is easier to remember to take them. It's also worth noting that side effects you experience when you start taking antidepressants may not last forever.
How long does it take for sertraline side effects to wear off? It usually takes 4 to 6 weeks for sertraline to work. Side effects such as feeling sick, headaches and trouble sleeping are common. They're usually mild and go away after a couple of weeks.
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