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What does Seroquel do to your brain? Quetiapine works in the brain, where it affects various neurotransmitters, in particular serotonin (5HT) and dopamine. Quetiapine works by blocking the receptors in the brain that dopamine acts on. This prevents the excessive activity of dopamine and helps to control symptoms of schizophrenia and manic depression.
When was clozapine developed? The potentially permanent movement disorder tardive dyskinesia occurs in about 5% of people. Its mechanism of action is not entirely clear. Clozapine was first made in 1958 and sold commercially in 1972. It was the first atypical antipsychotic.
Is clozapine controlled? Clozapine (marketed as Clozaril, Fazaclo ODT, Versacloz and generics) is an antipsychotic medicine used to treat schizophrenia in patients whose symptoms are not controlled with standard antipsychotic drugs. While clozapine is beneficial for some patients, there are risks associated with this drug.
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