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The cancers in IMPROVE-IT all occurred within less than 2 years; in SHARP, however, 3894 patients and 1022 patients have been followed for at least 3 years and 4 years, respectively.

The goals of preconception care are to 1) integrate the patient into the management of her diabetes, 2) achieve the lowest A1C test results possible without excessive hypoglycemia, 3) assure effective contraception until stable and acceptable glycemia is achieved, and 4) identify, evaluate, and treat long-term diabetic complications such as retinopathy, nephropathy, neuropathy, hypertension, and CAD.

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Patient is a premenopausal woman who is either surgically sterilized or highly unlikely to conceive, and has a negative urine beta-hCG pregnancy test within 72 hours prior to the start of study treatment.

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Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise.

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There is an increased risk of myopathy when simvastatin is used concomitantly with fibrates (especially gemfibrozil).

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Figure 4 Relative Risk of Death from Cancer in the SEAS Trial and in SHARP and IMPROVE-IT, According to Year of Onset.

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Perioperative chronic use of statins and the risk of muscle complaints in patients undergoing knee and hip endoprosthesis surgery.

Health care providers who care for children and adolescents, therefore, must be capable of evaluating the educational, behavioral, emotional, and psychosocial factors that impact implementation of a treatment plan and must work with the individual and family to overcome barriers or redefine goals as appropriate.

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These new recommendations regarding HBV vaccinations serve as a reminder to clinicians that children and adults with diabetes need a number of vaccinations, both those specifically indicated because of diabetes as well as those recommended for the general population ().

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Besides this thorough examination of the drugs ingredients and performance, the FDA also conducts periodic inspections of the manufacturing plants to ensure there are no changes in the approved drugs quality.

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This open-label, single-period study evaluated the single-dose pharmacokinetics of ezetimibe (EZE) 10 mg in the setting of steady-state cyclosporine (CyA) dosing in renal transplant patients.

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ULN) occurred in two (2%) individuals in the ZETIA coadministered with simvastatin group and in zero individuals in the simvastatin monotherapy group.

Concomitant use of these drugs and any medication labeled as having a strong inhibitory effect on CYP3A4 should be avoided unless the benefits of combined therapy outweigh the increased risk.

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In this latter group, statin assignment was not automatic, but was recommended to occur only after a clinician-patient risk discussion with shared decision making where other risk factors and lifestyle are addressed, the potential for benefit from a statin is weighed against the potential for adverse effects or drug drug interactions and informed patient preference is elicited.

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Although for most of these noncardiovascular causes, the number of deaths was slightly higher in the group given 80 mg of atorvastatin than in the group given 10 mg of atorvastatin, no single cause (according to body system or pathologic process) and no single type of cancer accounted for the nonsignificant difference in deaths from any cause between the groups.

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Gender: In a multiple-dose study with ezetimibe given 10 mg once daily for 10 days, plasma concentrations for total ezetimibe were slightly higher (less than 20%) in women than in men.

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In the presence of proliferative diabetic retinopathy (PDR) or severe nonproliferative diabetic retinopathy (NPDR), vigorous aerobic or resistance exercise may be contraindicated because of the risk of triggering vitreous hemorrhage or retinal detachment ().

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The mild ALT elevations associated with simvastatin therapy are usually self-limited and do not require dose modification; simvastatin should be stopped if ALT levels rise above 10-fold the upper limit of normal, or persist in being above 5-fold elevated or are associated with symptoms.

Comparative effectiveness of lifestyle intervention efforts in the community: results of the Rethinking Eating and ACTivity (REACT) study.

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