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The participant will identify some medications from some commonly seen classifications, as well as their actions, uses, adverse reactions and side effects, contraindications, and implications.
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Combination Lipid Therapy on Lipid Profiles in Patients with Impaired Glucose Tolerance.
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The cancers in IMPROVE-IT all occurred within less than 2 years; in SHARP, however, 3894 patients and 1022 patients have been followed for at least 3 years and 4 years, respectively.
The goals of preconception care are to 1) integrate the patient into the management of her diabetes, 2) achieve the lowest A1C test results possible without excessive hypoglycemia, 3) assure effective contraception until stable and acceptable glycemia is achieved, and 4) identify, evaluate, and treat long-term diabetic complications such as retinopathy, nephropathy, neuropathy, hypertension, and CAD.
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The results are not worth the long term side effect and serious muscle damage, plus possible heart damage.
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Patient is a premenopausal woman who is either surgically sterilized or highly unlikely to conceive, and has a negative urine beta-hCG pregnancy test within 72 hours prior to the start of study treatment.
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Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise.
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There is an increased risk of myopathy when simvastatin is used concomitantly with fibrates (especially gemfibrozil).
But ezetimibe plus simvastatin reduced the rate of cardiovascular death, myocardial infarction, or stroke by 2 percentage points (34.
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Multiple-dose studies of Ezetimibe given in combination with statins in rats and rabbits during organogenesis result in higher Ezetimibe and statin exposures.
This medication can cause birth defects in an unborn baby.
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Systems biology analysis unravels the complementary action of combined rosuvastatin and ezetimibe therapy.
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Figure 4 Relative Risk of Death from Cancer in the SEAS Trial and in SHARP and IMPROVE-IT, According to Year of Onset.
Is High-Intensity Statin Therapy Associated With Lower Statin Adherence Compared With Low- to Moderate-Intensity Statin Therapy?
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Clinician's Guide to the ABCs of Cardiovascular Disease Prevention: The Johns Hopkins Ciccarone Center for the Prevention of Heart Disease and American College of Cardiology Cardiosource Approach to the Million Hearts Initiative.
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Despite the preventable nature of many inpatient episodes of hypoglycemia, institutions are more likely to have nursing protocols for hypoglycemia treatment than for its prevention.
The SHARP randomised trial has now shown that lowering of LDL cholesterol with simvastatin plus ezetimibe safely reduces the risk of major atherosclerotic events in a wide range of patients with chronic kidney disease.
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Preliminary assessment of psychological and social status should be included as part of the medical management of diabetes.
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The worksheet, when shown to your doctors, may save you from being prescribed drugs that interact with each other or have other side effects that you might not have recognized as being drug-related.
Human cellular differences in cAMP - CREB signaling correlate with light-dependent melatonin suppression and bipolar disorder.
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Low High-Density Lipoprotein Cholesterol and Increased Cardiovascular Disease Risk: An Analysis of Statin Clinical Trials.
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In this article, we review 29 different medications that can have harmful interactions with thyroid medicines such as levothyroxine (Synthroid).
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Perioperative chronic use of statins and the risk of muscle complaints in patients undergoing knee and hip endoprosthesis surgery.
Health care providers who care for children and adolescents, therefore, must be capable of evaluating the educational, behavioral, emotional, and psychosocial factors that impact implementation of a treatment plan and must work with the individual and family to overcome barriers or redefine goals as appropriate.
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Current standards for diabetes management reflect the need to lower glucose as safely possible.
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When conflicting information is documented in the medical record, select Yes.
Studies show that for every 1% reduction in cholesterol levels there is a 2% reduction in the rate of heart disease.
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These new recommendations regarding HBV vaccinations serve as a reminder to clinicians that children and adults with diabetes need a number of vaccinations, both those specifically indicated because of diabetes as well as those recommended for the general population ().
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Refuse to abstain from food for at least 10 h prior to drug administration and for at least 4 h after dose in each period.
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If you overdose on Vytorin, immediately call your doctor or the poison control center, or go to the nearest hospital.
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Analysis and comparison of statin prescription patterns and outcomes according to clinical department.
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Besides this thorough examination of the drugs ingredients and performance, the FDA also conducts periodic inspections of the manufacturing plants to ensure there are no changes in the approved drugs quality.
Can a drug that impacts the absorption of intestinal cholesterol have an effect on the hypercholesterolemia and hypertriglyceridemia induced by the combination of modest dietary cholesterol in the presence of high levels of fat?
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This open-label, single-period study evaluated the single-dose pharmacokinetics of ezetimibe (EZE) 10 mg in the setting of steady-state cyclosporine (CyA) dosing in renal transplant patients.
As such, discharge planning begins at admission to the hospital and is updated as projected patient needs change.
There was no significant difference between groups in the numbers of hemorrhagic strokes as a first event.
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F3-JAK3 V674A and L540) while not having a significant effect in other cell lines (HDLM-2 and DU145) at the same concentration of 3uM.
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Simvastatin occasionally causes myopathy manifested as muscle pain, tenderness or weakness with creatine kinase above ten times the upper limit of normal (ULN).
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Consider documentation of a hold on an anticoagulant after discharge in one location and a listing of that anticoagulant as a discharge medication in another location as contradictory ONLY if the timeframe on the hold is not defined (e.
If your LDL cholesterol remains high, after changing your diet and exercise habits, your doctor may prescribe medications to lower it.
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ULN) occurred in two (2%) individuals in the ZETIA coadministered with simvastatin group and in zero individuals in the simvastatin monotherapy group.
Concomitant use of these drugs and any medication labeled as having a strong inhibitory effect on CYP3A4 should be avoided unless the benefits of combined therapy outweigh the increased risk.
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In this latter group, statin assignment was not automatic, but was recommended to occur only after a clinician-patient risk discussion with shared decision making where other risk factors and lifestyle are addressed, the potential for benefit from a statin is weighed against the potential for adverse effects or drug drug interactions and informed patient preference is elicited.
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Even though the data are not definitive, similar statin treatment approaches should be considered for patients with type 1 or type 2 diabetes, particularly in the presence of other cardiovascular risk factors.
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MRP4: a previously unidentified factor in resistance to nucleoside-based antiviral drugs.
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Reduction in weight and cardiovascular disease risk factors in individuals with type 2 diabetes: one-year results of the Look AHEAD trial.
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PP 5 (2009): A comprehensive assessment of cardiovascular risk involves consideration of socioeconomic deprivation, because it is an independent risk factor for CVD.
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Although for most of these noncardiovascular causes, the number of deaths was slightly higher in the group given 80 mg of atorvastatin than in the group given 10 mg of atorvastatin, no single cause (according to body system or pathologic process) and no single type of cancer accounted for the nonsignificant difference in deaths from any cause between the groups.
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Gender: In a multiple-dose study with ezetimibe given 10 mg once daily for 10 days, plasma concentrations for total ezetimibe were slightly higher (less than 20%) in women than in men.
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In the presence of proliferative diabetic retinopathy (PDR) or severe nonproliferative diabetic retinopathy (NPDR), vigorous aerobic or resistance exercise may be contraindicated because of the risk of triggering vitreous hemorrhage or retinal detachment ().
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Alcohol use and mortality from coronary heart disease: the role of high-density lipoprotein cholesterol.
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The mild ALT elevations associated with simvastatin therapy are usually self-limited and do not require dose modification; simvastatin should be stopped if ALT levels rise above 10-fold the upper limit of normal, or persist in being above 5-fold elevated or are associated with symptoms.
Comparative effectiveness of lifestyle intervention efforts in the community: results of the Rethinking Eating and ACTivity (REACT) study.
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The effect on triglycerides was minimal, and trends towards increased high-density lipoprotein cholesterol (HDL-C) and ApoA1 were observed compared with placebo.
Do not use if the medicine has changed colors or has particles in it.
After a solution of ezetimibe and the solid solution agent has been prepared, optionally including a heating treatment for making homogenous or evenly distributed solution, the liquid medium component used for preparing solid solution in liquid is evaporated.
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Ezetimibe formulations disclosed herein further promotes to provide a process for preparing a compressed ezetimibe tablet by dry granulation, moisture activated dry granulation (MADG), non-aqueous moisture activated dry granulation (NAMADG), double moisture activated dry granulation (DMADG), wet granulation, or fluid bed granulation in unit dosage form, without physical or chemical change of active principle.
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