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In one 16-week clinical trial of insulin plus ACTOS combination therapy, more patients developed congestive heart failure on combination therapy (1.

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Three randomized, double-blind, placebo-controlled trials with durations from 16 to 26 weeks were conducted to evaluate the use of Actos as monotherapy in patients with type 2 diabetes.

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It works by increasing the body's sensitivity to insulin, a natural substance that helps control blood sugar levels.

However, the risk of bladder cancer increased with increasing dose and duration of pioglitazone use.

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His lawsuit states the drug was "inadequately tested, dangerous to human health and lacked proper warnings.

Regulators in France and Germany pulled the medication from the shelves.

With several hundred federal cases pending, both Takeda and plaintiff attorneys filed to move all pending Actos lawsuits to one district court.

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Pancreatic cancer due to Actos has been reported in patients suffering from type 2 diabetes.

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The dose of your insulin might need to be changed.

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Treatment with ACTOS, as described, produced statistically significant improvements in HbA1c and FPG at endpoint compared to placebo (see Table 18).

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Se trata de que son actos mercantiles solo para una de las partes y en este sentido (y no en el rigurosamente técnico jurídico de efectos y contenido entre las partes) es en el que se emplea también la denominación de “unilateral”, por lo que es preferible esta terminología, para evitar la confusión llamándolos “mixtos”.

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French study of public insurance data confirmed that there is a slight increase in the risk of bladder cancer with Actos use, adding to the prior concerns about long-term use of the medication.

Pioglitazone may cause other side effects.

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